Endocrine Abstracts

A recognised complication of small cell lung cancer is adrenocorticotrophic hormone hypersecretion (ACTH). The profound biochemical derangement and subsequent symptomatology can be resistant to established medical therapeutic interventions. Our case illustrates the role of low risk palliative laparascopic surgery for resistant disease.Mr SR, a 47yr ex-smoker presented with breathlessness and haemoptysis of 3 months duration, there was no past medical or ...

Advanced glycation end products modify protein structure and function in type I diabetes. Glycoproteins may be potentially modified through other mechanisms, particularly changes to insulin-dependent oligosaccharide components. We have assessed the use of immobilised lectins, characterising the oligosaccharides of a serum glycoprotein, human chorionic gonadotrophin (hCG). We wish to test the hypothesis that glycoprotein glycosylation may be modified in type I diabetes.<p ...

The binding characteristics of maternal serum human chorionic gonadotrophin (hCG) to immobilised lectins, specifically Concanavalin A (Con A), Lens culinaris agglutinin (LCA) and Wheat germ agglutinin (WGA), have been shown be compatible with the proposed glycosyl structures of hCG as inferred from other analytical methods. We have shown that serum hCG from groups of pregnant women with or without type 1 diabetes show identical affinity for Con A and LCA, but serum hCG from th...